For instance, lawyer article human SET7/9 has just lately been reported to methylate Lys189 within the common transcription issue TAF10, resulting in an increased affinity for lawyer in my area RNA polymerase II and transcriptional activation of certain TAF10-dependent genes 37 SET7/9 has additionally been reported to methylate p53, lawyers rising the steadiness of this brief lived tumor-suppressor protein 38 These observations suggest that we should not narrowly define the SET-domain proteins as histone lysine methyltransferases however as an alternative name them protein lysine methyltransferases.